2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. 5-HT Receptor

5-HT Receptor

Serotonin Receptor; 5-hydroxytryptamine Receptor

5-HT Receptor

Related Products

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5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, as well as many hormones. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.

5-HT Receptor Isoform Specific Products:

5-HT Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-118127
    Rilapine
    		Antagonist
    Rilapine is an atypical antipsychotic agent.
    Rilapine
  • HY-W654010
    Lurasidone-d8-1 hydrochloride
    		Modulator
    Lurasidone-d8-1 (hydrochloride) is deuterium labeled Lurasidone (Hydrochloride). Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.
    Lurasidone-d<sub>8</sub>-1 hydrochloride
  • HY-30152R
    Xanthotoxol (Standard)
    		Antagonist
    Xanthotoxol (Standard) is the analytical standard of Xanthotoxol. This product is intended for research and analytical applications. Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC50s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation.
    Xanthotoxol (Standard)
  • HY-163728
    DSP-6745
    		Modulator
    DSP-6745 is a potent and orally active 5-HT Receptor inhibitor. DSP-6745 can be used in the study of depressive disorder.
    DSP-6745
  • HY-19238
    BMS-181885
    		Agonist
    BMS-181885 is a selective 5-HT1 receptor agonist and a ligand for 5-HT1B/1D receptors. BMS-181885 exhibits anti-migraine activity. BMS-181885 can be used in the research of neurological diseases such as migraine.
    BMS-181885
  • HY-B1942
    Diphenyl sulfone
    		Antagonist 99.97%
    Diphenyl sulfone (compound 10a) is a 5-HT6R antagonist with a Ki of 1.6 μM.
    Diphenyl sulfone
  • HY-17410S1
    Iloperidone-d3 hydrochloride
    		Antagonist
    Iloperidone-d3 hydrochloride is deuterated labeled Iloperidone (HY-17410). Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms.
    Iloperidone-d<sub>3</sub> hydrochloride
  • HY-182440
    AZD3783
    		Antagonist
    AZD3783 is an orally active, blood-brain barrier-penetrant 5-HT1B receptor antagonist. AZD3783 reverses agonist-induced hypothermia, inhibits separation-induced vocalizations in guinea pig pups, and acts as a moderately permeable glycoprotein substrate with moderate clearance. AZD3783 inhibits hERG channel activity. AZD3783 is applicable for research on depression, anxiety disorders, and other psychiatric diseases associated with serotonergic neurotransmission.
    AZD3783
  • HY-160656
    5-HT/NA Reuptake inhibitor-1
    5-HT/NA Reuptake inhibitor-1 (compound 9) is a selective dual 5-HT and NA reuptake inhibitor with IC50 of 660 nM and 70 nM respectively. . 5-HT/NA Reuptake inhibitor-1 has good in vitro human metabolic stability, hERG selectivity and passive membrane permeability.
    5-HT/NA Reuptake inhibitor-1
  • HY-103129A
    SB-200646
    		Antagonist
    SB-200646 is the first selective 5-HT2B/2C over 5-HT2A receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646 is orally active and has electrophysiological and anxiolytic properties in vivo.
    SB-200646
  • HY-A0171A
    Benzoctamine hydrochloride
    		Inhibitor
    Benzoctamine hydrochloride (Ba-30803) is a psychoactive agent with anti-anxiety effect. Benzoctamine hydrochloride blocks the central postsynaptic serotonin receptors and decreases 5-HT turnover in the brain.
    Benzoctamine hydrochloride
  • HY-101558A
    Elzasonan citrate
    		Antagonist
    Elzasonan citrate (CP-448187 citrate) is a 5-hydroxytryptamine1B receptor antagonist. Elzasonan is used in research on depression.
    Elzasonan citrate
  • HY-108324R
    (Z)-Thiothixene (Standard)
    		Antagonist
    (Z)-Thiothixene (Standard) is the analytical standard of (Z)-Thiothixene. This product is intended for research and analytical applications. (Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1.
    (Z)-Thiothixene (Standard)
  • HY-W344115
    Bicifadine
    		Inhibitor
    Bicifadine is an orally active serotonin/norepinephrine/dopamine triple reuptake inhibitor. Bicifadine is an effective antinociceptive in several models of acute, persistent, and chronic pain.
    Bicifadine
  • HY-14757
    Trelanserin
    		Antagonist
    Trelanserin (SL-650472) is a 5-HT receptor antagonist and also an effective in vitro smooth muscle contraction antagonist, competing against the contractions induced by sumatriptan (HY-B0121B) with a pA2 of 8.17±0.36.
    Trelanserin
  • HY-107125
    AVN-322
    		Antagonist
    AVN-322 is an orally active, highly selective 5-HT6Rantagonist for central nervous system disease research.
    AVN-322
  • HY-124186
    LR1143
    		Inhibitor
    LR1143 is a dopamine transporter (DAT) and 5-HT uptake inhibitor, with IC50 values of 3.4 nM and 112 nM in rats, respectively. LR1143 binds to DAT labeled with the dopamine reuptake inhibitor GBR 12935 (HY-12242A), with an IC50 of 4.4 nM. LR1143 shows lower selectivity for DAT than for serotonin reuptake sites. LR1143 can be used in studies related to cocaine abuse.
    LR1143
  • HY-176436S
    GW-117
    GW-117 is a 5-HT2C receptor antagonist and a melatonin (MT1/MT2) receptor agonist. GW-117 shows antidepressant-like and anxiolytic-like effects.
    GW-117
  • HY-B1115S1
    Buspirone-d8 dihydrochloride
    		Agonist
    Buspirone-d8 dihydrochloride is the deuterium labeled Buspirone hydrochloride (HY-B1115). Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research.
    Buspirone-d<sub>8</sub> dihydrochloride
  • HY-155330A
    PZ-1922 free base
    		Antagonist
    PZ-1922 free base is a BBB-penetrable 5-HT6R/5-HT3R antagonist (Ki: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively). PZ-1922 free base reversibly inhibits MAO-B (pIC50: 8.93). PZ-1922 free base reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 free base prevents Aβ-induced memory decline in the T-maze test.
    PZ-1922 free base
Cat. No. Product Name / Synonyms Application Reactivity
5-HT Receptor Isoform Comparison

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